paperApril 2026Unreviewed

TSAssistant: A Human-in-the-Loop Agentic Framework for Automated Target Safety Assessment

Xiaochen Zheng, Zhiwen Jiang, Melanie Guerard, Klas Hatje, Tatyana Doktorova

Abstract

Target Safety Assessment (TSA) requires systematic integration of heterogeneous evidence, including genetic, transcriptomic, target homology, pharmacological, and clinical data, to evaluate potential safety liabilities of therapeutic targets. This process is inherently iterative and expert-driven, posing challenges in scalability and reproducibility. We present TSAssistant, a multi-agent framework designed to support TSA report drafting through a modular, section-based, and human-in-the-loop par

Cite

@misc{zheng2026tsassistant,
  title = {{TSAssistant: A Human-in-the-Loop Agentic Framework for Automated Target Safety Assessment}},
  author = {Xiaochen Zheng and Zhiwen Jiang and Melanie Guerard and Klas Hatje and Tatyana Doktorova},
  year = {2026},
  month = apr,
  eprint = {2604.23938},
  archivePrefix = {arXiv},
  url = {https://arxiv.org/abs/2604.23938}
}